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Diseases and Conditions 2010

Consistent with this, boosting shuttle activity (via overexpression of their enzymes) decreased lactate accumulation and diverted more glucose into citrate with no impairment of proliferation 186 , also in agreement with an earlier notion that the Warburg effect is a consequence of limited NADH-shuttle throughput rather than a driver of proliferation 187

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doi: 10.1212/wnl.66.66_suppl_3.s13 32 HanJ.WangY.WeiP.LuD.ShanY